Weight loss medications like Ozempic, Wegovy, and Mounjaro have skyrocketed in popularity, thanks to their effectiveness in helping people shed pounds—sometimes dramatically. But with rapid weight loss and the rise of these medications comes a wave of new questions and unexpected side effects, including a phenomenon now widely known as “Ozempic Face.”

Let’s break down what Ozempic Face actually is, what causes it, and the other side effects you should know before considering weight loss injections.

What is Ozempic?

Ozempic is the brand name for semaglutide, a medication originally developed to treat type 2 diabetes. However, it has become widely used for weight loss after studies showed that it significantly reduces appetite and promotes sustained weight loss.

Wegovy is another brand of semaglutide, FDA-approved specifically for obesity and chronic weight management.

What is Ozempic Face?

“Ozempic Face” is a term used to describe the facial changes some people experience after significant, rapid weight loss, particularly while using weight loss medications like Ozempic or Wegovy.

Common Features of Ozempic Face:

• Hollow or sunken cheeks

• Sagging skin or loss of facial volume

• A gaunt or older appearance

Doctors and dermatologists say this is not specific to Ozempic—it’s actually a normal consequence of rapid fat loss, particularly in the face. When people lose a lot of weight quickly, the fat pads in the face diminish, leading to a more hollowed or aged appearance.

“It’s really just facial volume loss due to weight loss,” explains Dr. Paul Jarrod Frank, a celebrity dermatologist who coined the term. “It can happen with any kind of rapid weight loss, but we’re seeing more of it now because of these medications.”

Can Ozempic Face Be Treated?

Yes. Many people turn to cosmetic treatments to counteract the effects:

• Dermal fillers (like Juvederm or Restylane) to restore lost volume

• Skin tightening treatments such as radiofrequency or ultrasound

• Fat grafting for longer-lasting results

Of course, these are optional and cosmetic, and the facial changes are not dangerous—just a cosmetic consideration for some users.

Other Common Side Effects of Weight Loss Meds

Weight loss medications work by mimicking hormones that affect appetite and digestion, which can lead to a variety of side effects. Here’s what else to expect:

1. Nausea and Gastrointestinal Issues

• Nausea, vomiting, and diarrhea are among the most common side effects when starting semaglutide-based meds.

• These usually subside over time as your body adjusts.

2. Constipation or Bloating

• Slower digestion can lead to irregular bowel movements.

• Drinking water and increasing fiber intake helps manage this.

3. Fatigue and Low Energy

• Some users report feeling tired, especially early in the treatment.

• This may be due to reduced calorie intake or blood sugar changes.

4. Hair Thinning

• Rapid weight loss in general can sometimes trigger telogen effluvium, a temporary form of hair loss.

• It usually resolves as the body stabilizes.

5. Muscle Loss

• When weight is lost too quickly, muscle mass may be reduced along with fat.

• It’s important to include strength training and protein in your routine to maintain muscle.

Serious (But Rare) Side Effects

While most side effects are mild or manageable, there are more serious potential risks:

• Pancreatitis

• Gallbladder issues

• Kidney problems

• Thyroid tumors (seen in animal studies; unclear in humans)

Always discuss your medical history with a healthcare provider before starting these medications.

Final Thoughts

Weight loss medications like Ozempic and Wegovy can be incredibly effective tools, especially for people struggling with obesity or related health conditions. But like all medical treatments, they come with potential side effects—cosmetic and physical.

“Ozempic Face” is not a disease or a dangerous condition; it’s simply a reflection of fast weight loss, particularly visible in the face. Being aware of all side effects—and having a plan to manage them—can help users navigate this weight loss journey more confidently and safely.

Always consult your doctor before starting or stopping any weight loss medication.